Genetics in diabetes: Type 2 diabetes and related trait
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چکیده
منابع مشابه
Genetics in diabetes: Type 2 diabetes and related traits
The past decade has seen unprecedented progress in the understanding of the genetic basis of type-2 diabetes (T2D), fuelled largely by technological advancement. This has led to large scale studies such as various genome-wide association studies (GWAS). The undercurrent of this book is in defining the genetic basis of T2D and related traits from the perspective of current advancement in genomic...
متن کاملGenetics of Type 2 Diabetes- A Review Article
Objective: Type 2 diabetes (T2D) as a complex disease is the result of genetically heterogeneous factors and environmental issues interaction. Linkage and small-scale candidate gene studies were successful in identification of genetic susceptibilities of monogenic form of diseases. However, they were largely unsuccessful while applying to the more common forms of disease. By designing Genome Wi...
متن کاملGenetics of type 2 diabetes.
Identification and characterization of genetic variants that either cause or predispose to diabetes are a major focus of biomedical research. As of early 2007, the molecular basis of most forms of monogenic diabetes resulting from beta-cell dysfunction is known and, in particular, there has been recent success in delineating the genetic aetiology of neonatal diabetes. Finding genes predisposing...
متن کاملGenetics of type 2 diabetes.
BACKGROUND Type 2 diabetes (T2D) is a complex disorder that is affected by multiple genetic and environmental factors. Extensive efforts have been made to identify the disease-affecting genes to better understand the disease pathogenesis, find new targets for clinical therapy, and allow prediction of disease. CONTENT Our knowledge about the genes involved in disease pathogenesis has increased...
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The successful application of positional cloning, the process of disease susceptibility gene identification using gene mapping techniques, to identify the gene underlying cystic fibrosis (1) opened the era of gene hunting. The subsequent identification of susceptibility genes underlying numerous monogenic disorders led to the possibility that susceptibility genes for complex diseases could also...
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ژورنال
عنوان ژورنال: Indian Journal of Medical Research
سال: 2016
ISSN: 0971-5916
DOI: 10.4103/0971-5916.192084